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The “dead zone” in the Gulf of Mexico – a region of oxygen-depleted water off the Louisiana and Texas coasts that is harmful to sea life and the commercial fishing industry – is predicted to be the largest ever recorded this year, federal scientists announced Tuesday.

The unusually large size of the zone is due to the extreme flooding of the Mississippi River this spring.

The dead zone occurs when there is not enough oxygen in the water to support marine life. Also known as “hypoxia,” it is created by nutrient runoff, mostly from over-application of fertilizer on agricultural fields. It flows into streams, then rivers and eventually the Gulf.

Forty-one percent of the contiguous USA drains into the Mississippi River and then out to the Gulf of Mexico. The majority of the land in Mississippi’s watershed is farm land.

Excess nutrients such as nitrogen can spur the growth of algae, and when the algae die, their decay consumes oxygen faster than it can be brought down from the surface, according to the National Oceanic and Atmospheric Administration (NOAA). As a result, fish, shrimp and crabs can suffocate, threatening the region’s commercial fishing industry.