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George McGovern, the United States senator who won the Democratic Party’s presidential nomination in 1972 as an opponent of the war in Vietnam and a champion of liberal causes, and who was then trounced by President Richard M. Nixon in the general election, died early Sunday in Sioux Falls, S.D. He was 90.

His death was announced in a statement by the family. He had been moved to hospice care in recent days after being treated for several health problems in the last year. He had a home in Mitchell, S.D., where he had spent his formative years.

“We are blessed to know that our father lived a long, successful and productive life advocating for the hungry, being a progressive voice for millions and fighting for peace,” the family statement said.

To the liberal Democratic faithful, Mr. McGovern remained a standard-bearer well into his old age, writing and lecturing even as his name was routinely invoked by conservatives as synonymous with what they considered the failures of liberal politics.