Search OCA
Get Local!

Variant CJD susceptibility

December 12, 2001 Journal of the American Medical Asssociation JAMA, 
Vol. 286 No. 22,
http://jama.ama-assn.org/issues/current/ffull/jwm10013-3.html

People who lack a particular variant of a gene involved in the immune response may, according to a new study by scientists in England and cited in this study, be three times more likely to develop variant Creutzfeldt-Jakob (vCJD) syndrome.

The investigators, from University College London, National Blood Service, Royal Free and University College Medical School, all in London, and Oxford Radcliffe Hospitals, Oxford, reported their findings in the November 15 issue of Nature.

The gene, called DQ7, is one of several variants of a gene that is part of the human leukocyte antigen (HLA) complex, a cluster of genes that play a role in presenting peptides, such as from bacteria, to the immune system. The researchers found that only 12% of 50 patients with vCJD had this genetic variant compared with nearly 36% of controls.

If the finding that DQ7 has a protective effect is confirmed, it "should aid differential diagnosis and may have important implications for understanding susceptibility to infection by [bovine spongiform encephalopathy] prions, and the distinctive pathogenesis of vCJD, as well as in the identification of targets for prevention and therapy of vCJD," they said.


Home | News | Organics | GE Food | Health | Environment | Food Safety | Fair Trade | Peace | Farm Issues | Politics
Forum | Español | Campaigns | Buying Guide | Press | Search | Volunteer | Donate | About Us | Contact Us | Email This Page

Organic Consumers Association - 6771 South Silver Hill Drive, Finland MN 55603
E-mail: Staff · Activist or Media Inquiries: 218-226-4164 · Fax: 218-353-7652
Please support our work. Send a tax-deductible donation to the OCA

Fair Use Notice: The material on this site is provided for educational and informational purposes. It may contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. It is being made available in an effort to advance the understanding of scientific, environmental, economic, social justice and human rights issues etc. It is believed that this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have an interest in using the included information for research and educational purposes. If you wish to use copyrighted material from this site for purposes of your own that go beyond 'fair use', you must obtain permission from the copyright owner. The information on this site does not constitute legal or technical advice.
Please Support Our Sponsors!

Organic Valley

Organic
Valley

Dr. Bronner's Magic Soaps

Dr. Bronner's
Magic Soaps

Botani Organic

Botani
Organic

Aloha Bay

Aloha Bay

Eden Organics

Eden Foods

Frey Vineyards

Frey
Vineyards

Intelligent Nutrients

Intelligent
Nutrients