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Mad Cow Disease May Have Spread into Sheep

Experts discover first signs of BSE in sheep
The Independent (UK)

By Steve Connor, Science Editor

08 April 2004

Scientists have detected the first signs that bovine spongiform
encephalopathy (BSE) may have crossed into sheep in a study that is likely
to rekindle anxieties over the safety of lamb and mutton.

One of three tests used to determine whether sheep that had seemingly died
from scrapie were in fact infected with BSE (also known as "mad cow"
disease) has produced positive results. The four-year-old animal was thought
to have developed scrapie, a brain disorder that affects sheep and is
believed to be harmless to humans.

It died in January and its brain was tested by the Veterinary Laboratories
Agency (VLA) in Weybridge, Surrey, as part of a national programme to
determine whether BSE has become endemic in sheep. Two of the three tests
were negative for BSE but the third gave "some characteristics" that were
similar to experimental BSE in sheep, the Department for the Environment,
Food and Rural Affairs (Defra) said.

Scientific experts who carried out the tests have nevertheless concluded
that the case "could not be considered to be" BSE, although they have not
ruled out the possibility that this is the first case of BSE disease in
sheep. "Some characteristics [of the test] were similar to experimental BSE
in sheep and also to [an] experimental strain of sheep scrapie," Defra said.

It was always theoretically possible for sheep to be infected with BSE
because they were once fed the same infected material that had spread the
brain disease in cattle during the 1980s and early 1990s. But there is no
simple test to distinguish BSE from sheep scrapie, and sheep experimentally
infected with BSE show the same symptoms as scrapie, which means that
scrapie in the field could be masking a hidden BSE epidemic in sheep.

Scientists at the VLA are now testing the sheep's brain with more a
sophisticated method based on long-term mouse experiments, which should
within two years determine whether the animal really did have BSE or a
simply a new strain of scrapie. Defra said that in the meantime the lack of
further evidence to suggest that the animal had BSE as opposed to scrapie
meant that the existing rules governing the sale of lamb and sheep offal
remained unchanged.

Professor Howard Dalton, chief scientific adviser to Defra, said: "As we
continue to assess more samples with these improved methods it is likely
that we will continue to find samples, such as this, which fall outside our
current knowledge of the disease."

The Food Standards Agency said that until there is firm evidence that BSE is
present in the national sheep flock there is no need to change existing
rules governing the sale of lamb products, such as intestines, which could
carry a higher risk of being infected with BSE.

Experiments suggest that BSE could be easily transmitted to sheep, and it
could, like scrapie, be passed down the generations. This would mean that
BSE could still be infecting the national flock today, more than a decade
after meat and bonemeal was banned.