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Study: Tumeric & Curried Cauliflower Prevent Prostate Cancer

Curried Cauliflower Effective Against Prostate Cancer
Environment News Service
http://www.ens-newswire.com/ens/jan2006/2006-01-16-01.asp

RUTGERS, New Jersey, January 16, 2006 (ENS) - Turmeric, the mild spice that
gives curry its deep yellow color, appears to have good potential for the
treatment and prevention of prostate cancer, particularly when combined with
certain vegetables, Rutgers University scientists have discovered.
The scientists tested turmeric, also known as curcumin, along with phenethyl
isothiocyanate (PEITC), a naturally occurring substance particularly
abundant in a group of vegetables including broccoli, Brussels sprouts,
cabbage, cauliflower, kale, kohlrabi turnips, and watercress.
"The bottom line is that PEITC and curcumin, alone or in combination,
demonstrate significant cancer-preventive qualities in laboratory mice, and
the combination of PEITC and curcumin could be effective in treating
established prostate cancers," said Ah-Ng Tony Kong, a professor of
pharmaceutics at Rutgers.

Professor Ah-Ng Tony Kong studies cancer prevention and treatment at Rutgers
University's Ernest Mario School of Pharmacy. (Photo courtesy Rutgers)
The discovery was announced in the January 15 issue of the journal "Cancer
Research" by Kong and his colleagues at Rutgers' Ernest Mario School of
Pharmacy.

Prostate cancer is the second leading cause of cancer death in men in the
United States, with a half-million new cases appearing each year.
The incidence and mortality of prostate cancer have not decreased in past
decades despite tremendous efforts and resources devoted to treatment. This
is because advanced prostate cancer cells are barely responsive even to high
concentrations of chemotherapeutic agents or radiotherapy.
The authors observed that by comparison to the high incidence of prostate
cancer in the United States, the incidence of this disease is low in India
where people eat large amounts of plant foods rich in phytochemicals ­
nonnutritive plant chemicals that have protective or disease-preventive
properties.

As a result, the scientists have been investigating intervention options
based on compounds found in edible and medicinal plants. They have had some
success, and a majority of patients with prostate cancer are now combining
the conventional therapies with these compounds as alternative,
supplementary or complementary medications.

For Kong's study, researchers used mice bred so that their immune systems
would not reject foreign biological material. They injected the mice with
cells from human prostate cancer cell lines to grow tumors against which the
compounds could be tested.

"Despite convincing data from laboratory cell cultures, we knew little about
how PEITC and curcumin would perform in live animals, especially on prostate
cancer," Kong said. "So we undertook this study to evaluate how effective
PEITC and curcumin might be ­ individually and in combination ­ to prevent
and possibly treat prostate cancer."

The researchers injected the mice with curcumin or PEITC, alone or in
combination, three times a week for four weeks, beginning a day before the
introduction of the prostate cancer cells.

They found the injections "significantly retarded" the growth of cancerous
tumors. Using PEITC and curcumin in tandem produced even stronger effects.
The group then evaluated the therapeutic potential of curcumin and PEITC in
mice with well-established tumors, and the results showed that PEITC or
curcumin alone had little effect. But when curcumin and PEITC were given in
tandem, tumor growth was "significantly reduced."

The paper, "Combined Inhibitory Effects of Curcumin and Phenethyl
Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in
Immunodeficient Mice," is available at cancerres.aacrjournals.org.

The authors are Tin Oo Khor, Young-Sam Keum, Wen Lin, Jung-Hwan Kim, Rong
Hu, Guoxiang Shen, Changjiang Xu, Avanthika Gopalakrishnan, Bandaru Reddy,
Xi Zheng, AllanConney and Ah-Ng Tony Kong, all from Rutgers.