Environmental health expert says low doses of the most ubiquitous toxics are hurting people—updating how we test and regulate could save lives.

We’ve all heard the old adage—”the dose makes the poison.” Well—for many pollutants—it may be time to reexamine that.

Some of the most common, extensively tested chemicals — radon, lead, particulate matter, asbestos, tobacco and benzene — appear to be proportionally more harmful to a person’s health at the lower levels of exposure, according to a new review of decades of research.

“Not only is there no apparent safe levels or thresholds, but at the lowest levels of exposure, there is a steeper increase in the risk,” said author Dr. Bruce Lanphear, a professor and researcher at Simon Fraser University.

The key word here is proportionally—smoking three packs of cigarettes a day for 40 years is obviously worse for your lungs than a little secondhand smoke from time to time. However, the point is that for the nonsmoker exposed to secondhand smoke, the risk is “extraordinarily large,” Lanphear said.

Lanphear, a renowned environmental health expert, has for years been a leading voice on how low levels of lead can have big impacts on kids’ health. In a commentary published in today’s PLOS Biology journal he summarizes key research on low levels of exposure to lead and other toxics and argues, in largely ignoring such exposures, most health and regulatory agencies are not fully protecting public health.

“For toxic chemicals without a threshold … we will inevitably fail to prevent most deaths, diseases, and disabilities, like obesity, heart disease, diabetes, and cancer, until we expand our focus to include population strategies that target people who have low-to-moderate exposures,” he wrote.

Lanphear acknowledges it’s a tough concept to wrap your head around—most people, including health professionals, think of safe levels or thresholds for toxics.

“If we took this research seriously, we could prevent a lot of death and disease and disability,” Lanphear said. “And that makes me hopeful.”