As drug-resistant infections become more prevalent, so are cases of sepsis — a progressive disease process initiated by an aggressive, dysfunctional immune response to an infection in the bloodstream, which is why it’s sometimes referred to as blood poisoning. Unless caught and treated early, the condition can progress to septic shock, resulting in extremely low blood pressure, weakening of the heart, multiple organ failure and death.

An estimated 1 million Americans develop sepsis each year^1,2 and up to 50 percent die from the systemic infection.^3,4,5 While illnesses such as bronchitis, pneumonia, strep throat, kidney infection or even localized infections can turn septic, sepsis is most commonly acquired in hospital settings.^6,7 Unfortunately, conventional treatment often fails, as evidenced by the 50 percent mortality rate.

It’s also costly. According to the Agency for Healthcare Research and Quality, sepsis is the most expensive condition being treated in U.S. hospitals, racking up expenses in excess of $24 billion in 2014.⁸ There’s good news though. Recently, evidence for not just one but two different nondrug treatments have emerged, both of which show remarkable promise.

Infants Saved by Probiotics

Sepsis can occur in just about anyone, including infants. Recent research^9,10 shows feeding newborns probiotics (healthy bacteria) significantly lowers the child’s risk of developing sepsis. The study involved infants in rural India, where sepsis is common. Worldwide, an estimated 600,000 infants die from sepsis, primarily in developing countries.

The bacterial strain selected was Lactobacillus plantarum ATCC-202195 — a kind of lactic acid bacteria found in fermented vegetables such as sauerkraut and kimchi.¹¹ To that, they added the prebiotic fructooligosaccharide “to promote growth and sustain colonization of the probiotic strain.”

The bacterial strain was chosen by methodically prescreening more than 280 strains in preliminary studies. Lactobacillus plantarum was in part chosen for its ability to attach to cells in the gut. According to NPR,¹² the team was “shocked by how well the bacteria worked.” In infants given the synbiotic mix (probiotic plus prebiotic) for one week, the risk of sepsis and death dropped by 40 percent, from 9 to 5.4 percent.

A total of 149 villages in Odisha state, India — where infant mortality is the highest in the nation — were included in the study. While the team was initially planning to enroll 8,000 infants, the study was halted after the enrollment of 4,557 babies. Due to the clear evidence of significant benefit, it would have been unethical to continue depriving half of the newborns of the treatment.

Probiotic Also Lowered Other Infection Rates

The probiotic also reduced a number of other common infections. Respiratory infections, for example, were reduced by 34 percent, which was entirely unexpected. Gram-positive bacterial infections were reduced by 82 percent and gram-negative infections (which are more difficult to treat) dropped by 75 percent. Another major benefit is the price. At a cost of about $1 per infant per weeklong course of treatment, it’s incredibly affordable.

The researchers note that probiotics may be more powerful than drugs for a number of reasons. For starters, the beneficial bacteria help control harmful bacteria that may otherwise overtake the baby’s gut. The probiotic also generates compounds that strengthen the intestinal wall, thereby preventing harmful bacteria from entering the bloodstream. It also helps bolster and promote healthier maturation of the baby’s immune system.