The Senate on Sunday approved a sweeping package to combat climate change, lower health-care costs, raise taxes on some billion-dollar corporations and reduce the federal deficit, as Democrats overcame months of political infighting to deliver the centerpiece to President Biden’s long-stalled economic agenda.

The party-line vote was a milestone in a tumultuous journey that began last year when Democrats took control of Congress and the White House with a promise to bring financial relief to ordinary Americans. With a tiebreaking vote from Vice President Harris, the 50-50 Senate sent the bill to the House, which aims to approve it and send it to the White House for Biden’s signature later this week.

Dubbed the Inflation Reduction Act of 2022, the package would authorize the biggest burst of spending in U.S. history to tackle global warming — about $370 billion to reduce greenhouse gas emissions to 40 percent below their 2005 levels by the end of this decade.