1. I know about biological warfare/biodefense. I am the first person in the world (according to publicly available literature) to have analyzed an epidemic and demonstrated that the epidemic was due to biological warfare. (1992 study of the 1978-1980 Rhodesian anthrax outbreak, published in Medicine and Global Survival, aka Physicians for Social Responsibility Quarterly (name changed), hosted by International Physicians for the Prevention of Nuclear War). https://www.ippnw.org/pdf/mgs/psr-2-4-nass.pdf
2. Prior to genetic engineering techniques being developed (1973) and widely used (since late 1970s), more ‘primitive’ means of causing mutations, with the intention of developing biological weapons, were employed. Such methods were used by the Japanese beginning in the 1930s, by the US beginning in the 1940s, and by a number of other countries. They resulted in biological weapons that were tested, well-described, and in some cases, used. Such methods were also used subsequent to the 1970s.