Thirty years of gain-of-function experiments have not delivered any significant benefits such as cures or safe vaccines, clearly showing that the risks substantially outweigh the benefits. Therefore, after evaluating the benefits versus the risks of gain-of-function experimentation, we the undersigned call for a US and global moratorium on all gain-of-function experiments. The moratorium will stay in place until the UN Secretary General calls a head-of-state-level Summit on the hazards of gain-of-function research; and recommendations are made and implemented to improve biosecurity and ensure that no pandemic biological threats will result from this research.Read more