Egypt Rat Study Shows Intestinal Damage
from Bt-Spliced Food

Egyption Study Shows Bt-Spliced Food Damages the Intestines of Lab Rats
On 30 Dec 2000, at 13:18, jcummins wrote:

The article below provides disturbing evidence that regulators in US
and Canada select evidence supporting safety of GM crops and ignore good
evidence of injury. Bt Cry 1 is used in millions of acres of food
crops approved for human consumption. The evidence below that the Bt
Cry 1 damages the ileum is very clear and should not have been
ignored. After the abstract I have included discussion of the ileum.
The damaged ileum would cause distress to digestion and is likely
diagnosed as mild food poisoning or flu. The fact that GM crops are
unlabelled means that the problems people experience after consuming GM
food cannot be recognized and treated. What I am saying is that cry 9
was approved for animals because of its evident allergenicity in rats.
The evidence that cry 1 (which was approved for human consumption)
damaged the ileum was hidden from consumers!

Toxins Volume 6, Issue 6, 1998. Pages: 219-233
Published Online: 29 Jun 1999
Research Article

Fine Structural Changes in the Ileum of Mice Fed on -Endotoxin-
Treated Potatoes and Transgenic Potatoes Nagui H. Fares 1 *, Adel K.
El-Sayed 2 1Department of Zoology, Faculty of Science, Ain
Shams University, Cairo, Egypt 2Department of Entomology, Faculty of
Science, Ain Shams University, Cairo, Egypt

email: Nagui H. Fares (nfares@asunet.shams.eun

Abstract The present work has been designed to study the effect of
feeding on transgenic potatoes, which carry the CryI gene of Bacillus
thuringiensis var. kurstaki strain HD1, on the light and electron
microscopic structure of the mice ileum, in comparison with feeding on
potatoes treated with the -endotoxin isolated from the same bacterial
strain. The microscopic architecture of the enterocytes of the ileum
of both groups of mice revealed certain common features such as the
appearance of mitochondria with signs of degeneration and disrupted
short microvilli at the luminal surface. However, in the group of mice
fed on the -endotoxin, several villi appeared with an abnormally large
number of enterocytes (151.8 in control group versus 197 and 155.8 in
endotoxin and transgenic-treated groups, respectively). Fifty percent
of these cells were hypertrophied and multinucleated. The mean area of
enterocyte was significantly increased (105.3 µm2 in control group
versus 165.4 µm2 and 116.5 µm2 in endotoxin and transgenic-treated
groups, respectively). Several forms of secondary lysosomes or
auotophagic vacuoles were recognized in these cells. These changes
were confirmed with the scanning electron microscope which revealed a
remarkable increase in the topographic contour of enterocytes (23 µm
in control group versus 44 µm and 28 µm in endotoxin and
transgenic-treated groups, respectively) at the divulged surface of
the villi. The basal lamina along the base of the enterocytes was
damaged at several foci. Several disrupted microvilli appeared in
association with variable-shaped cytoplasmic fragments. Some of these
fragments contained endoplasmic reticulum, as well as ring-shaped
annulate lamellae. In addition, the Paneth cells were highly activated
and contained a large number of secretory granules. These changes may
suggest that -endotoxin-treated potatoes resulted in the development
of hyperplastic cells in the mice ileum. Although mild changes are
reported in the structural configuration of the ileum of mice fed on
transgenic potatoes, nevertheless, thorough tests of these new types
of genetically engineered crops must be made to avoid the risks before
marketing. Copyright © 1998 John Wiley & Sons, Ltd.
Ileum final and longest segment of the small intestine. It is specifically
responsible for the absorption of vitamin B12 and the reabsorption
of conjugated bile salts . The ileum is about 4 m (13 feet) in length
and extends from the jejunum (the middle section of the small intestine)
to the ileocecal valve, which empties into the colon (large intestine).
The ileum is suspended from the abdominal wall by the mesentery.
The smooth muscle of the ileum's walls is thinner than the walls of
other parts of the intestines, and its peristaltic contractions are slower.
The ileum's lining is also less permeable than that of the upper small
intestine. Small collections of lymphatic tissue (Peyer's patches) are
embedded in the ileal wall, and specific receptors for bile salts and
vitamin B12 are contained exclusively in its lining; about 90 percent
of the conjugated bile salts in the intestinal contents is absorbed by
the ileum.

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